Agasti 17, 2015 |Izixhobo kunye nezixhobo, izixhobo zeLabhoratri kunye nezixhobo zebhubhoratri, iindaba zeLabhoratri, iinkqubo zeLabhoratri, iLabhoratri yezifo, uvavanyo lwaseLabhoratri
Ngokubeka esi sixhobo esingabizi kakhulu, esiphuhliswe kwiYunivesithi yaseWisconsin-Madison, engalweni okanye esiswini, izigulane zinokuqokelela igazi labo ekhaya ngemizuzu.
Ngaphezu kweminyaka emibini, amajelo eendaba aseMelika athabathekile ngumbono weTheranos CEO uElizabeth Holmes wokubonelela izigulane ezidinga uvavanyo lwegazi ngovavanyo lwegazi lweminwe endaweni ye-venipuncture.Ngeli xesha, iilebhu zophando kwilizwe liphela zisebenzela ukuphuhlisa iindlela zokuqokelela iisampulu zovavanyo lwelebhu yezonyango ezingafuni naliti kwaphela.
Ngomzamo onjalo, inokungena kwimarike ngokukhawuleza.Esi sisixhobo sokuqokelela igazi esingenayo inaliti ebizwa ngokuba yiHemoLink, ephuhliswe liqela lophando kwiYunivesithi yaseWisconsin-Madison.Abasebenzisi babeka nje isixhobo esilingana nebhola yegalufa engalweni okanye esiswini imizuzu emibini.Ngeli xesha, isixhobo sitsala igazi kwi-capillaries kwisitya esincinci.Emva koko isigulane siya kuthumela ityhubhu yegazi eliqokelelweyo kwibhubhoratri yonyango ukuze ihlalutywe.
Esi sixhobo esikhuselekileyo sifanelekile kubantwana.Nangona kunjalo, izigulana ezifuna uvavanyo lwegazi rhoqo ukuze zibeke iliso kwimpilo yazo nazo ziyakuxhamla njengoko zibasindisa kuhambo oluthe rhoqo ukuya kwiilebhu zeklinikhi ukutsala igazi ngendlela yokuhlaba inaliti yesintu.
Kwinkqubo ebizwa ngokuthi "isenzo se-capillary," i-HemoLink isebenzisa i-microfluidics ukwenza i-vacuum encinci ekhupha igazi kwii-capillaries ngokusebenzisa iziteshi ezincinci esikhumbeni kwii-tubules, i-Gizmag ibika.Isixhobo siqokelela i-0.15 cubic centimeters yegazi, eyaneleyo ukufumanisa i-cholesterol, izifo, iiseli zomhlaza, iswekile yegazi kunye nezinye iimeko.
Iingcali zePathologists kunye neengcali zelebhu yeklinikhi ziya kubukela uphehlelelo lokugqibela lwe-HemoLink ukubona ukuba abaphuhlisi bayo bazoyisa njani iingxaki ezichaphazela ukuchaneka kovavanyo lwaselabhoratri ezinokubangelwa lulwelo lwe-interstitial oluhlala luhamba negazi le-capillary xa kuqokelela iisampulu ezinjalo.Indlela itekhnoloji yokuvavanya elebhu esetyenziswa yiTheranos inokusombulula ingxaki efanayo ibe yeyona nto kugxilwe kuyo kwiilebhu zonyango.
I-Tasso Inc., isiqalo sezonyango esaphuhlisa i-HemoLink, yasekwa ngabaphandi abathathu ababesakuba yi-UW-Madison microfluidics:
ICasavant ichaza isizathu sokuba i-microfluidic force isebenze: “Kweli nqanaba, ukuxinezeleka komphezulu kubaluleke ngakumbi kunomxhuzulane, kwaye kugcina igazi kumjelo kungakhathaliseki ukuba usibambe njani isixhobo,” watsho kwingxelo yeGizmag.
Le projekthi yaxhaswa ngemali ye-3 yezigidi nge-Arhente yeeProjekthi zoPhando oluPhezulu lwezoKhuselo (i-DARPA), ingalo yophando yeSebe lezoKhuselo laseMelika (DOD).
Abathathu abasebenzisana nabo baseTasso, Inc., abaphandi bangaphambili be-microfluidics kwiYunivesithi yaseWisconsin-Madison (ukusuka kwesobunxele ukuya kwesokudla): uBen Casavant, iSekela likaMongameli weMisebenzi kunye nobuNjineli, u-Erwin Berthier, iSekela likaMongameli wezoPhando kunye noPhuhliso kunye neTekhnoloji, kunye noBen Moga, uMongameli, kwivenkile yekofu wakhulelwa ingcamango yeHemoLink.(Ilungelo lokushicilela ifoto iTasso, Inc.)
Isixhobo se-HemoLink sincinci ukuvelisa kwaye i-Tasso inethemba lokuyenza ifumaneke kubathengi kwi-2016, ngokutsho kweGizmag.Nangona kunjalo, oku kunokuxhomekeka ekubeni izazinzulu zeTasso zinokuphuhlisa indlela yokuqinisekisa ukuzinza kweesampuli zegazi.
Okwangoku, iisampulu ezininzi zegazi zovavanyo lwelabhoratri yeklinikhi zifuna ukuthuthwa kwikhonkco elibandayo.Ngokwengxelo yeGizmag, izazinzulu zeTasso zifuna ukugcina iisampulu zegazi kwi-140 degrees Fahrenheit kangangeveki ukuqinisekisa ukuba ziyavavanywa xa zifika kwilebhu yeklinikhi ukuze ziqwalaselwe.I-Tasso iceba ukufaka isicelo sokukhutshwa kwe-US Food and Drug Administration (FDA) ekupheleni kwalo nyaka.
I-HemoLink, indleko ephantsi yokuchithwa kwesixhobo sokuqokelela igazi elingenanaliti, inokufumaneka kubathengi kwi-2016. Isebenzisa inkqubo ebizwa ngokuthi "isenzo se-capillary" ukutsala igazi kwi-tube yokuqokelela.Abasebenzisi bayibeka nje engalweni okanye esiswini imizuzu emibini, emva koko ityhubhu ithunyelwe kwilebhu yezonyango ukuze ihlalutywe.(Ilungelo lokushicilela ifoto iTasso, Inc.)
I-HemoLink ziindaba ezimnandi kubantu abangazithandi iinaliti zeenaliti kunye nabahlawuli abakhathalela ukuthotywa kweendleko zempilo.Ukongeza, ukuba i-Tasso iyaphumelela kwaye ivunyiwe yi-FDA, inokuphinda ibonelele abantu kwihlabathi liphela - nakwiindawo ezikude - ngokukwazi ukunxibelelana kwiilebhu zovavanyo lwegazi kunye nokuxhamla kuxilongo oluphezulu.
"Sinedatha enyanzelisayo, iqela lokulawula elinobundlobongela kunye neemfuno zeklinikhi ezingafezekanga kwimarike ekhulayo," kusho uModja kwingxelo yeGizmag."Ukwandisa ukhathalelo lwasekhaya ngokuqokelela igazi elikhuselekileyo nelifanelekileyo lokuxilongwa kweklinikhi kunye nokubeka iliso luhlobo lwezinto ezintsha ezinokuphucula iziphumo ngaphandle kokunyusa iindleko zonyango."
Kodwa ayingabo bonke abachaphazelekayo kwishishini lelebhu yezonyango abaya kuvuya malunga nokuqaliswa kweemarike zeHemoLink.Yitekhnoloji enokuthi iguqule umdlalo kuzo zombini iilabhoratri zeklinikhi kunye nenkampani yaseSilicon Valley biotech iTheranos, echithe izigidi zeedola igqibelelisa indlela eyenza ngayo uvavanyo lwegazi oluntsonkothileyo kwiisampulu zegazi, USA TODAY iingxelo.
Kuya kuba yinto ehlekisayo ukuba abaphuhlisi be-HemoLink banokusombulula nayiphi na imiba ngeteknoloji yabo, bafumane imvume ye-FDA, kwaye bazise ukuthengisa imveliso kwiinyanga ezizayo ze-24 eziphelisa imfuno ye-venipuncture kunye nesampuli yeminwe.Iintlobo ezininzi zovavanyo lwebhubhoratri yezonyango.Oku kuqinisekileyo kukuba "indudumo ehamba phambili" e-Theranos, ethe kule minyaka mibini idlulileyo ivakalisa umbono wayo wokutshintsha imboni yovavanyo lwelebhu yeklinikhi njengoko isebenza namhlanje.
ITheranos ikhetha iPhoenix Metro kwiFlegi yokuTyala ukuze ingene kwiMarike yoVavanyo lweLabhoratri yoKhuphiswano
Ngaba iTheranos ingatshintsha imarike yovavanyo lwelabhoratri yeklinikhi?Injongo yokujonga amandla, uxanduva kunye nemingeni ekufuneka iqwalaselwe
Andiqondi ukuba kuqhubeka ntoni apha.Ukuba itsala igazi eluswini, ayenzi indawo yegazi, ebizwa ngokuba yihickey?Ulusu lu-avascular, ngoko luyenza njani?Ngaba ukho umntu onokuchaza ezinye zezibakala zenzululwazi ezibangela oku?Ndicinga ukuba licebo elihle… kodwa ndingathanda ukwazi ngakumbi.Enkosi
Andiqinisekanga ukuba le nto isebenza kakuhle kangakanani-iTheranos ayikhuphi ulwazi oluninzi.Kwezi ntsuku zimbalwa zidlulileyo, baye bafumana nezaziso zokuyeka nokuyeka.Ukuqonda kwam ezi zixhobo kukuba zisebenzisa "i-clumps" ephezulu ye-capillaries esebenza njengenaliti.Asenokushiya amabala aqaqamba kancinane, kodwa andiqondi ukuba ukungena kukonke kulusu kunzulu njengenaliti (umz. Akkuchek).